More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy
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| Автор |
Chegodaev, D.
Pavlova, P. Kiselev, S. |
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| Тематика |
ELECTROENCEPHALOGRAPHY
GABA-A RECEPTOR AGONISTS INFANT SLEEP 4 AMINOBUTYRIC ACID ARTICLE BRAIN ELECTROPHYSIOLOGY BRAIN MATURATION DEPOLARIZATION ELECTROENCEPHALOGRAPHY ELECTROPHYSIOLOGICAL PROCEDURES GABAERGIC TRANSMISSION HUMAN INFANCY INFANT NONHUMAN NONREM SLEEP PHENOTYPE POSTNATAL DEVELOPMENT SLEEP SPINDLE |
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| Описание |
Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but there is a large body of literature that indicates the relationship between spindle activity and neural plasticity. Many of the spindle parameters (frequency, configuration, duration, density, and topography) vary significantly throughout life. However, the long duration, asynchrony and sharp morphology are the most distinctive characteristics of sleep spindles in infants. This unique infantile phenotype of sleep spindles typically changes after approximately one year of postnatal life in humans. Considering that EEG reflects brain electrochemical activity, there is evidence to suggest that substantial neurochemical events underlie these changes. In this paper, we hypothesize that the GABA (gammaaminobutyric acid) shift is a key event influencing the sleep spindle phenotype during infancy. We briefly review evidence for the relation between infantile sleep spindles and depolarizing GABA transmission occurring in the developing brain. © 2022 Brazilian Association of Sleep and Latin American Federation of Sleep Societies. All rights reserved.
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| Дата |
2024-04-08T11:07:35Z
2024-04-08T11:07:35Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Chegodaev, D, Pavlova, P & Kiselev, S 2022, 'More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy', Sleep Science, Том. 15, № 4, стр. 459-462. https://doi.org/10.5935/1984-0063.20220079
Chegodaev, D., Pavlova, P., & Kiselev, S. (2022). More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy. Sleep Science, 15(4), 459-462. https://doi.org/10.5935/1984-0063.20220079 1984-0659 Final All Open Access; Gold Open Access; Green Open Access https://sleepscience.org.br/export-pdf/3368/v15n4a13.pdf https://sleepscience.org.br/export-pdf/3368/v15n4a13.pdf http://elar.urfu.ru/handle/10995/131484 10.5935/1984-0063.20220079 85142396528 000888024800013 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Brazilian Association of Sleep and Latin American Federation of Sleep Societies
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| Источник |
Sleep Science
Sleep Science |
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