Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3- a ]azines as Potential HSF1 Inductors
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3- a ]azines as Potential HSF1 Inductors
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| Автор |
Serebrennikova, P. O.
Utepova, I. A. Chupakhin, O. N. Guzhova, I. V. Mikhaylova, E. R. Antonchick, A. P. |
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| Тематика |
AZOLOAZINE
CYCLIZATION HETEROAROMATIC HSF1 INDUCTORS HYPERVALENT IODINE(III) METALLOCENE CYCLIZATION (DIACETOXYIODO)BENZENE 1 (5 BROMOTHIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOLINE 1 (5 BROMOTHIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE 1 (THIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOLINE 1 (THIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE 1 (THIOPHEN 3 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOLINE 1 (THIOPHEN 3 YL) [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE 1 CYMANTRENYL [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE 1 FERROCENYL [1,2,4]TRIAZOLO[4,3 A]QUINOLINE 1 FERROCENYL [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE 1,2,4 TRIAZINE DERIVATIVE 1,2,4 TRIAZOLO[4,3 A]AZINE DERIVATIVE 2 (2 (THIOPHEN 2 YLMETHYLENE)HYDRAZINYL)PYRIMIDINE 2 AZINYLHYDRAZONE DERIVATIVE 2,6 BIS(5,7 DIMETHYL[1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 3 YL)PYRIDINE 2,6 BIS([1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 3 YL)PYRIDINE 2,6 BIS([1,2,4]TRIAZOLO[4,3 A]QUINOLIN 1 YL)PYRIDINE 2,6 BIS([1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 YL)PYRIDINE 3 (5 BROMOTHIOPHEN 2 YL) 5,7 DIMETHYL [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 (5 BROMOTHIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 (THIOPHEN 2 YL) 1,2,4 TRIAZOLO[4,3 A]PYRIMIDINE 3 (THIOPHEN 3 YL) [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 CYMANTRENYL 5,7 DIMETHYL[1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 CYMANTRENYL [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 FERROCENYL 5,7 DIMETHYL[1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 3 FERROCENYL [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 5,7 DIMETHYL 3 (THIOPHEN 2 YL) [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE 5,7 DIMETHYL 3 (THIOPHEN 3 YL) [1,2,4]TRIAZOLO[4,3 A]PYRIMIDINE ALDEHYDE AZINYLHYDRAZINE DERIVATIVE BENZENE FERROCENE CARBOXALDEHYDE HEAT SHOCK PROTEIN 70 HUNTINGTIN HYDRAZINE DERIVATIVE HYDRAZONE DERIVATIVE IODINE DERIVATIVE METALLOCENE ALDEHYDE PYRIMIDINE DERIVATIVE QUINOXALINE DERIVATIVE UNCLASSIFIED DRUG [BIS(TRIFLUOROACETOXY)IODO]BENZENE AZOLOAZINE CYCLIZATIONS HETEROAROMATICS HSF1 INDUCTOR HSP70 EXPRESSION HYDRAZONES HYPERVALENT IODINE HYPERVALENT IODINE(III) ONE POT OXIDATIVE CYCLIZATION ANIMAL CELL ARTICLE ASSAY C6 CELL LINE (GLIOMA) CELL DEATH CELL VIABILITY CONFOCAL MICROSCOPY CONTROLLED STUDY CRYSTAL STRUCTURE CYCLIZATION CYTOTOXICITY FILTER TRAP ASSAY HELA CELL LINE HUMAN HUMAN CELL INTRAMOLECULAR CYCLIZATION NONHUMAN ONE POT SYNTHESIS OXIDATIVE CYCLIZATION PC12 CELL LINE (PHEOCHROMOCYTOMA) POLYMERIZATION PROTEIN AGGREGATION PROTEIN EXPRESSION RAT REACTION OPTIMIZATION SH-SY5Y CELL LINE SYNTHESIS T98G CELL LINE WESTERN BLOTTING X RAY CRYSTALLOGRAPHY ORGANOMETALLICS |
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| Описание |
Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine( III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation. © 2022 Georg Thieme Verlag. All rights reserved.
Ministry of Science and Higher Education of the Russian Federation, (13.1902.21.0027, N 075-15-2020-795) The research was supported by Ministry of Science and Higher Education of Russia, Research Project N 075-15-2020-795, local identifier 13.1902.21.0027.MinisyofScienceandHigherEducatonofheRusianFedeation075152020795(local identier13.1902.21.0027) |
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| Дата |
2024-04-08T11:07:44Z
2024-04-08T11:07:44Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) info:eu-repo/semantics/acceptedVersion |
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| Идентификатор |
Serebrennikova, PO, Utepova, IA, Chupakhin, ON, Guzhova, IV, Mikhaylova, ER & Antonchick, AP 2022, 'Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3- a ]azines as Potential HSF1 Inductors', Synthesis (Germany), Том. 54, № 11, стр. 2677-2686. https://doi.org/10.1055/s-0040-1719907
Serebrennikova, P. O., Utepova, I. A., Chupakhin, O. N., Guzhova, I. V., Mikhaylova, E. R., & Antonchick, A. P. (2022). Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3- a ]azines as Potential HSF1 Inductors. Synthesis (Germany), 54(11), 2677-2686. https://doi.org/10.1055/s-0040-1719907 0039-7881 Final All Open Access; Green Open Access https://irep.ntu.ac.uk/id/eprint/46274/1/1543235_Antonchick.pdf https://irep.ntu.ac.uk/id/eprint/46274/1/1543235_Antonchick.pdf http://elar.urfu.ru/handle/10995/131507 10.1055/s-0040-1719907 85127365826 000770124100001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
Georg Thieme Verlag
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| Источник |
Synthesis
Synthesis (Germany) |
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