Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts
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| Автор |
Bazhutina, A.
Balakina-Vikulova, N. A. Kursanov, A. Solovyova, O. Panfilov, A. Katsnelson, L. B. |
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| Тематика |
CARDIAC ELECTROMECHANICS
CELL MODELLING FIBROBLASTS BIOMECHANICAL PHENOMENA CALCIUM CELL COMMUNICATION ELECTROPHYSIOLOGY FIBROBLASTS GAP JUNCTIONS ION CHANNELS MODELS, BIOLOGICAL MODELS, THEORETICAL MYOCARDIUM MYOCYTES, CARDIAC POTASSIUM RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL SARCOPLASMIC RETICULUM SODIUM CALCIUM ION CHANNEL POTASSIUM RYANODINE RECEPTOR SODIUM BIOLOGICAL MODEL BIOMECHANICS CARDIAC MUSCLE CARDIAC MUSCLE CELL CELL COMMUNICATION CYTOLOGY ELECTROPHYSIOLOGY FIBROBLAST GAP JUNCTION METABOLISM PHYSIOLOGY SARCOPLASMIC RETICULUM THEORETICAL MODEL |
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| Описание |
Cardiac fibroblasts are interspersed within mammalian cardiac tissue. Fibroblasts are mechanically passive; however, they may communicate electrically with cardiomyocytes via gap junctions and thus affect the electrical and mechanical activity of myocytes. Several in-silico studies at both cellular (0D) and ventricular (3D) levels analysed the effects of fibroblasts on the myocardial electrical function. However, none of them addressed possible effects of fibroblast-myocyte electrical coupling to cardiomyocyte mechanical activity. In this paper, we propose a mathematical model for studying both electrical and mechanical responses of the human cardiomyocyte to its electrotonic interaction with cardiac fibroblasts. Our simulations have revealed that electrotonic interaction with fibroblasts affects not only the mechanical activity of the cardiomyocyte, comprising either moderate or significant reduction of contractility, but also the mechano-calcium and mechano-electric feedback loops, and all these effects are enhanced as the number of coupled fibroblasts is increased. Obtained results suggest that moderate values of the myocyte-fibroblast gap junction conductance (less than 1 nS) can be attributed to physiological conditions, contrasting to the higher values (2 nS and higher) proper rather for pathological situations (e.g. for infarct and/or border zones), since all mechanical indexes falls down dramatically in the case of such high conductance. © 2020 Elsevier Ltd
Russian Foundation for Basic Research, РФФИ, (18-01-00059, 18-29-13008) The work was carried out within the framework of the IIP UrB RAS, Russia theme No AAAA-A18-118020590031-8 , and was supported by the Russian Foundation for Basic Research (RFBR), Russia ( 18-29-13008 , 18-01-00059 ) and by RF Government Act #211, Russia of March 16, 2013 (agreement 02.A03.21.0006 ). |
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| Дата |
2024-04-22T15:53:11Z
2024-04-22T15:53:11Z 2021 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Bazhutina, A, Balakina-Vikulova, NA, Kursanov, A, Solovyova, O, Panfilov, A & Katsnelson, LB 2021, 'Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts', Progress in Biophysics and Molecular Biology, Том. 159, стр. 46-57. https://doi.org/10.1016/j.pbiomolbio.2020.08.003
Bazhutina, A., Balakina-Vikulova, N. A., Kursanov, A., Solovyova, O., Panfilov, A., & Katsnelson, L. B. (2021). Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts. Progress in Biophysics and Molecular Biology, 159, 46-57. https://doi.org/10.1016/j.pbiomolbio.2020.08.003 0079-6107 Final All Open Access; Green Open Access https://biblio.ugent.be/publication/8711535/file/8711541 https://biblio.ugent.be/publication/8711535/file/8711541 http://elar.urfu.ru/handle/10995/132406 45312304 10.1016/j.pbiomolbio.2020.08.003 85090303429 609424100006 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by-nc-nd |
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| Формат |
application/pdf
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| Издатель |
Elsevier Ltd
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| Источник |
Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology |
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