The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns
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| Автор |
Costa, F. V.
Rosa, L. V. Quadros, V. A. de Abreu, M. S. Santos, A. R. S. Sneddon, L. U. Kalueff, A. V. Rosemberg, D. B. |
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| Тематика |
ANTI-PAIN MEDICATION SCREENING
NOCICEPTORS NON-TRADITIONAL PAIN MODELS NOXIOUS STIMULI PAIN-RELATED BEHAVIORS ZEBRAFISH ANALGESICS ANIMALS DISEASE MODELS, ANIMAL PAIN TRANSLATIONAL RESEARCH, BIOMEDICAL ZEBRAFISH ACETIC ACID ACID SENSING ION CHANNEL ALLYL ISOTHIOCYANATE CINNAMALDEHYDE DOPAMINE 2 RECEPTOR ENDOCANNABINOID FORMALDEHYDE FREUND ADJUVANT G PROTEIN COUPLED RECEPTOR HISTAMINE MORPHINE NALOXONE NORBINALTORPHIMINE OPIATE RECEPTOR TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANALGESIC AGENT BEHAVIOR CHANGE BRAIN DEVELOPMENT CENTRAL NERVOUS SYSTEM DRUG SCREENING EXPERIMENTAL BEHAVIORAL TEST FIN CLIPPING LOCOMOTION MOOD DISORDER NERVE CELL PLASTICITY NOCICEPTIVE STIMULATION NONHUMAN PAIN PAIN RECEPTOR PERIAQUEDUCTAL GRAY MATTER REVIEW SENSORY GANGLION SENSORY NERVE CELL SURGICAL TECHNIQUE TAIL BEAT RATE TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY A MEMBER 1 GENE TRANSLATIONAL PAIN RESEARCH TRIGEMINUS GANGLION ZEBRA FISH ANIMAL DISEASE MODEL GENETICS PAIN |
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| Описание |
The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) is a powerful aquatic model for modeling pain responses. Here, we summarize the molecular machinery of zebrafish responses to painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms underlying pain responses from evolutionary and translational perspectives. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood disorders, as well as to facilitate analgesic therapy screening in translational pain research. © 2022 Bentham Science Publishers.
International Zebrafish Neuroscience Research Con sortium PROEX, (23038.005450/2020-19) Sirius University ZNRC Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, FAPERGS, (19/2551-0001764-2) Russian Science Foundation, RSF, (20-65-46006) National Centre for the Replacement Refinement and Reduction of Animals in Research, NC3Rs Funding text 1: F.V.C., V.A.Q., and L.C.R. received CAPES fellowship. D.B.R. and A.R.S. are recipients of CNPq research productivity grant. D.B.R. research is also supported by PROEX/CAPES (process number 23038.005450/2020-19) and Programa PQ-Gaúcho FAPERGS (process number 19/2551-0001764-2) fellowship grants. A.V.K. is the Chair of the International Zebrafish Neuroscience Research Con- Funding text 2: F.V.C., V.A.Q., and L.C.R. received CAPES fellowship. D.B.R. and A.R.S. are recipients of CNPq research productivity grant. D.B.R. research is also supported by PROEX/CAPES (process number 23038.005450/2020-19) and Programa PQ-Ga?cho FAPERGS (process number 19/2551-0001764-2) fellowship grants. A.V.K. is the Chair of the International Zebrafish Neuroscience Research Con sortium (ZNRC). His research is supported by the Russian Science Foundation (RSF) grant 20-65-46006. L.U.S. is convenor of the FELASA working group producing a report on Pain Management in Zebrafish and is a member of the NC3Rs (UK) expert panel on zebrafish welfare. The funders did not influence writing and submission of this manuscript. Funding text 3: sortium (ZNRC). His research is supported by the Russian Science Foundation (RSF) grant 20-65-46006. L.U.S. is convenor of the FELASA working group producing a report on Pain Management in Zebrafish and is a member of the NC3Rs (UK) expert panel on zebrafish welfare. The funders did not influence writing and submission of this manuscript. Funding text 4: The authors thank the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-Finance Code 001, and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS). AVK collaboration is supported by Sirius University, Sochi, Russia. |
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| Дата |
2024-04-22T15:53:38Z
2024-04-22T15:53:38Z 2022 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Costa, FV, Rosa, LV, Quadros, VA, de Abreu, MS, Santos, ARS, Sneddon, LU, Kalueff, AV & Rosemberg, DB 2022, 'The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns', Current Neuropharmacology, Том. 20, № 3, стр. 476-493. https://doi.org/10.2174/1570159X19666210311104408
Costa, F. V., Rosa, L. V., Quadros, V. A., de Abreu, M. S., Santos, A. R. S., Sneddon, L. U., Kalueff, A. V., & Rosemberg, D. B. (2022). The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns. Current Neuropharmacology, 20(3), 476-493. https://doi.org/10.2174/1570159X19666210311104408 1570-159X Final All Open Access; Green Open Access https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608236 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608236 http://elar.urfu.ru/handle/10995/132469 10.2174/1570159X19666210311104408 85126831080 811614400003 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by |
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| Формат |
application/pdf
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| Издатель |
Bentham Science Publishers
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| Источник |
Current Neuropharmacology
Current Neuropharmacology |
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