Functional heterogeneity arising due to electrical and mechanical interactions between cardial myocytes in mathematical model of homogeneous myocardial fiber
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Functional heterogeneity arising due to electrical and mechanical interactions between cardial myocytes in mathematical model of homogeneous myocardial fiber
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| Автор |
Kursanov, A. G.
Katsnelson, L. B. Vikulova, N. A. Solovyova, O. E. Markhasin, V. S. |
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| Тематика |
CARDIAC MECHANO-ELECTRIC FEEDBACK
CARDIOMYOCYTE INTERACTION COOPERATIVITY EXCITATION-CONTRACTION COUPLING MYOCARDIUM CONTRACTION |
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| Описание |
We developed a mathematical model describing heart muscle strand as a one-dimensional continuous medium of cardiomyocytes, through which electrical excitation propagates and excites the cells for contraction. Intracellular excitation-contraction coupling is presented by means of our earlier published model describing mechanical function of the cardiomyocyte evoked by action potential development and calcium activation of cross-bridge formation. The whole strand model simulates also mechanical interaction between the cardiomyocytes in the tissue and accounts for both intracellular and intercellular electro-mechanical coupling and mechano-electric feedback mechanisms. Numerical experiments with the strand formed of initially identical cardiomyocytes revealed that electrical and mechanical interaction between the cells, as well as intracellular mechano-electric feedbacks caused pronounced nonuniformity of their behavior. Model analysis suggests that cooperative mechanisms of myofilament calcium activation play the key role in dynamic adjustment of electrical and mechanical activity of the interacting cardiomyocytes in the tissue. © 2015.
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| Дата |
2024-04-22T18:30:03Z
2024-04-22T18:30:03Z 2015 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Курсанов, А. Г. and Kursanov, A. G. (2015) ‘Функциональная неднородность возникающая в результате электрического и механического взаимодействия между кардиомиоцитами в математической модели однородного волокна’, Математическая биология и биоинформатика. Institute of Mathematical Problems of Biology of RAS (IMPB RAS), 10(2), pp. 436–454. doi: 10.17537/2015.10.436.
Курсанов, А. Г., & Kursanov, A. G. (2015). Функциональная неднородность возникающая в результате электрического и механического взаимодействия между кардиомиоцитами в математической модели однородного волокна. Математическая Биология и Биоинформатика, 10(2), 436–454. doi:10.17537/2015.10.436 1994-6538 Final All Open Access, Bronze https://doi.org/10.17537/2015.10.436 http://elar.urfu.ru/handle/10995/132503 25374130 10.17537/2015.10.436 85010908751 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
Russian Academy of Sciences
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| Источник |
Математическая биология и биоинформатика
Mathematical Biology and Bioinformatics |
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