Subchronic systemic toxicity and bioaccumulation of Fe3O 4 nano- and microparticles following repeated intraperitoneal administration to rats
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Subchronic systemic toxicity and bioaccumulation of Fe3O 4 nano- and microparticles following repeated intraperitoneal administration to rats
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| Автор |
Katsnelson, B. A.
Degtyareva, T. D. Minigalieva, I. I. Privalova, L. I. Kuzmin, S. V. Yeremenko, O. S. Kireyeva, E. P. Sutunkova, M. P. Valamina, I. I. Khodos, M. Y. Kozitsina, A. N. Shur, V. Y. Vazhenin, V. A. Potapov, A. P. Morozova, M. V. Шур, В. Я. |
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| Тематика |
MAGNETITE
NANOPARTICLES SUBCHRONIC TOXICITY FERRIC OXIDE IRON NANOPARTICLE WATER ANIMAL EXPERIMENT ANIMAL TISSUE ARTICLE ATOMIC ABSORPTION SPECTROMETRY BIOACCUMULATION CHEMICAL ANALYSIS CONTROLLED STUDY DRUG PENETRATION ELECTRON SPIN RESONANCE FEMALE FUNCTIONAL ASSESSMENT HISTOPATHOLOGY INTRAPERITONEAL DRUG ADMINISTRATION IRON BLOOD LEVEL LIVER NONHUMAN PARTICLE SIZE PHOTOMETRY RAT SPLEEN TOXICITY TOXICOKINETICS ANIMALS ELECTRON SPIN RESONANCE SPECTROSCOPY FEMALE FERROSOFERRIC OXIDE INJECTIONS, INTRAPERITONEAL IRON LIVER METAL NANOPARTICLES PARTICLE SIZE RATS SPECTROPHOTOMETRY, ATOMIC SPLEEN TOXICITY TESTS RATTUS |
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| Описание |
Aqueous suspensions of 10 nm, 50 nm, or 1 μm Fe3O4 particles were injected intraperitoneally (ip) to rats at a dose of 500 mg/kg in 4 mL of sterile deionized water 3 times a week for 5 weeks. Following exposure, functional and biochemical indices and histopathological examinations of spleen and liver tissues of exposed rats were evaluated for signs of toxicity. The iron content of the blood was measured photometrically, and that of the liver and the spleen by atomic adsorption spectroscopy (AAS) and electron paramagnetic resonance (EPR) methods. It was found that, given equal mass doses, Fe3O4 nanoparticles possess considerably higher systemic toxicity than microparticles, but within the nanometric range the relationship between particle size and resorptive toxicity is intricate and nonunique. The latter fact may be attributed to differences in different nanoparticles' toxicokinetics, which are controlled by both more or less substantial direct penetration of nanoparticles through biological barriers and their unequal solubility. © The Author(s) 2011.
The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: Financial support provided by Russian Federal Agency of Science and Innovations. |
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| Дата |
2024-04-24T12:38:25Z
2024-04-24T12:38:25Z 2011 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Katsnelson, B. A., Degtyareva, T. D., Minigalieva, I. I., Privalova, L. I., Kuzmin, S. V., Yeremenko, O. S., … Morozova, M. V. (2011). Subchronic systemic toxicity and bioaccumulation of Fe3O4 nano- and microparticles following repeated intraperitoneal administration to rats. International Journal of Toxicology, 30(1), 59–68. doi:10.1177/1091581810385149
1091-5818 Final All Open Access, Bronze https://journals.sagepub.com/doi/pdf/10.1177/1091581810385149 http://elar.urfu.ru/handle/10995/132591 10.1177/1091581810385149 84911450734 000345961800020 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
SAGE Publications
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| Источник |
International Journal of Toxicology
International Journal of Toxicology |
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